Structure-Specific Ribonucleases for MS-Based Elucidation of Higher-Order RNA Structure
نویسندگان
چکیده
منابع مشابه
Chemical probes for higher-order structure in RNA.
Three chemical reactions can probe the secondary and tertiary interactions of RNA molecules in solution. Dimethyl sulfate monitors the N-7 of guanosines and senses tertiary interactions there, diethyl pyrocarbonate detects stacking of adenosines, and an alternate dimethyl sulfate reaction examines the N-3 of cytidines and thus probes base pairing. The reactions work between 0 degrees C and 90 d...
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ژورنال
عنوان ژورنال: Journal of The American Society for Mass Spectrometry
سال: 2014
ISSN: 1044-0305,1879-1123
DOI: 10.1007/s13361-014-0911-2